Coronavirus (COVID-19)

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Coronavirus (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus, first identified in late 2019. It can cause a wide range of symptoms, from mild respiratory illness to severe pneumonia, multi-organ failure, or death. The disease triggered a global pandemic with significant health, economic, and social impacts.


🦠 CAUSATIVE AGENT

  • Virus: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

  • Family: Coronaviridae (same family as SARS and MERS)


🔍 HOW IT SPREADS

ModeDetails
Respiratory dropletsCoughing, sneezing, talking
Airborne particlesEspecially in enclosed, poorly ventilated spaces
Contact transmissionTouching contaminated surfaces, then mouth/nose/eyes
AerosolsFine particles that can linger in the air longer than droplets

📈 INCUBATION PERIOD

  • Typically 2–14 days, average ~5 days


😷 SYMPTOMS OF COVID-19

CommonLess CommonSevere
FeverSore throatShortness of breath
CoughMuscle achesChest pain or pressure
FatigueHeadacheBluish lips or face
Loss of smell/tasteNausea/diarrheaConfusion, difficulty waking
Nasal congestionSkin rashesOxygen saturation < 94%

Some individuals remain asymptomatic but can still spread the virus.


📊 WHO IS AT HIGHER RISK?

  • Older adults (65+)

  • People with chronic diseases (diabetes, heart/lung/kidney disease)

  • Immunocompromised individuals

  • Pregnant people

  • Obese individuals (BMI ≥ 30)


🧪 DIAGNOSIS

TestDescription
RT-PCRGold standard; detects viral RNA
Rapid antigen testQuick, less sensitive
Serology (antibody tests)Detect past infection or vaccine response

💊 TREATMENT OPTIONS

🔹 1. For Mild to Moderate Cases (Home care)

  • Rest and hydration

  • Paracetamol or ibuprofen for fever/pain

  • Pulse oximeter to monitor oxygen levels

  • Isolation to prevent transmission


🔹 2. Antiviral Therapies

MedicationUse
Paxlovid (nirmatrelvir + ritonavir)Oral antiviral for high-risk patients
RemdesivirIV antiviral for hospitalized patients
MolnupiravirFor mild/moderate cases, less widely used

🔹 3. Immunomodulators (for moderate/severe)

  • Corticosteroids (e.g., dexamethasone) to reduce lung inflammation

  • IL-6 inhibitors (e.g., tocilizumab) in cytokine storm cases


🔹 4. Supportive Hospital Care

  • Oxygen therapy

  • Mechanical ventilation (for respiratory failure)

  • ECMO (Extracorporeal Membrane Oxygenation) in critical cases

  • Anticoagulants (to prevent blood clots)


🛡️ PREVENTION

  • Vaccination: Primary series + boosters (based on age & risk)

  • Face masks: Especially in crowded/public settings

  • Hand hygiene: Regular washing or sanitizer

  • Ventilation: Keep indoor spaces well-aired

  • Isolation: If infected or symptomatic


🧬 VARIANTS OF CONCERN

VariantNotes
Alpha, Beta, DeltaPrevious waves
Omicron & subvariants (e.g., XBB, BA.2.86)Highly transmissible but less severe
Current surveillanceContinues globally through genomic sequencing

💉 VACCINES

TypeExamples
mRNAPfizer-BioNTech, Moderna
Viral vectorAstraZeneca, J&J
Inactivated virusSinopharm, Covaxin
Protein subunitNovavax

Boosters target updated Omicron strains in many countries.

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