Coronavirus (COVID-19)
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Coronavirus (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus, first identified in late 2019. It can cause a wide range of symptoms, from mild respiratory illness to severe pneumonia, multi-organ failure, or death. The disease triggered a global pandemic with significant health, economic, and social impacts.
🦠 CAUSATIVE AGENT
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Virus: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
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Family: Coronaviridae (same family as SARS and MERS)
🔍 HOW IT SPREADS
| Mode | Details |
|---|---|
| Respiratory droplets | Coughing, sneezing, talking |
| Airborne particles | Especially in enclosed, poorly ventilated spaces |
| Contact transmission | Touching contaminated surfaces, then mouth/nose/eyes |
| Aerosols | Fine particles that can linger in the air longer than droplets |
📈 INCUBATION PERIOD
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Typically 2–14 days, average ~5 days
😷 SYMPTOMS OF COVID-19
| Common | Less Common | Severe |
|---|---|---|
| Fever | Sore throat | Shortness of breath |
| Cough | Muscle aches | Chest pain or pressure |
| Fatigue | Headache | Bluish lips or face |
| Loss of smell/taste | Nausea/diarrhea | Confusion, difficulty waking |
| Nasal congestion | Skin rashes | Oxygen saturation < 94% |
Some individuals remain asymptomatic but can still spread the virus.
📊 WHO IS AT HIGHER RISK?
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Older adults (65+)
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People with chronic diseases (diabetes, heart/lung/kidney disease)
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Immunocompromised individuals
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Pregnant people
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Obese individuals (BMI ≥ 30)
🧪 DIAGNOSIS
| Test | Description |
|---|---|
| RT-PCR | Gold standard; detects viral RNA |
| Rapid antigen test | Quick, less sensitive |
| Serology (antibody tests) | Detect past infection or vaccine response |
💊 TREATMENT OPTIONS
🔹 1. For Mild to Moderate Cases (Home care)
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Rest and hydration
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Paracetamol or ibuprofen for fever/pain
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Pulse oximeter to monitor oxygen levels
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Isolation to prevent transmission
🔹 2. Antiviral Therapies
| Medication | Use |
|---|---|
| Paxlovid (nirmatrelvir + ritonavir) | Oral antiviral for high-risk patients |
| Remdesivir | IV antiviral for hospitalized patients |
| Molnupiravir | For mild/moderate cases, less widely used |
🔹 3. Immunomodulators (for moderate/severe)
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Corticosteroids (e.g., dexamethasone) to reduce lung inflammation
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IL-6 inhibitors (e.g., tocilizumab) in cytokine storm cases
🔹 4. Supportive Hospital Care
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Oxygen therapy
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Mechanical ventilation (for respiratory failure)
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ECMO (Extracorporeal Membrane Oxygenation) in critical cases
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Anticoagulants (to prevent blood clots)
🛡️ PREVENTION
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Vaccination: Primary series + boosters (based on age & risk)
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Face masks: Especially in crowded/public settings
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Hand hygiene: Regular washing or sanitizer
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Ventilation: Keep indoor spaces well-aired
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Isolation: If infected or symptomatic
🧬 VARIANTS OF CONCERN
| Variant | Notes |
|---|---|
| Alpha, Beta, Delta | Previous waves |
| Omicron & subvariants (e.g., XBB, BA.2.86) | Highly transmissible but less severe |
| Current surveillance | Continues globally through genomic sequencing |
💉 VACCINES
| Type | Examples |
|---|---|
| mRNA | Pfizer-BioNTech, Moderna |
| Viral vector | AstraZeneca, J&J |
| Inactivated virus | Sinopharm, Covaxin |
| Protein subunit | Novavax |
Boosters target updated Omicron strains in many countries.

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