Epilepsy

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Epilepsy is a neurological disorder marked by recurrent, unprovoked seizures caused by abnormal electrical activity in the brain. Seizures can vary from brief lapses in attention or muscle jerks to severe convulsions and loss of consciousness.


⚡ WHAT IS A SEIZURE?

  • seizure is a sudden surge of electrical activity in the brain.

  • Not all seizures are due to epilepsy — other causes include fever, alcohol withdrawal, or head trauma.

  • Epilepsy is diagnosed when two or more unprovoked seizures occur >24 hours apart.


🧠 TYPES OF EPILEPSY & SEIZURES

🔹 Focal (Partial) Seizures – Affect one area of the brain

TypeSymptoms
Focal aware (simple partial)Fully conscious; unusual sensations or movements
Focal impaired awarenessConfusion, unresponsiveness, repetitive motions (e.g., lip-smacking)

🔹 Generalized Seizures – Involve both sides of the brain

TypeSymptoms
Tonic-clonic (grand mal)Convulsions, stiffening, jerking, loss of consciousness
Absence (petit mal)Staring spells, brief loss of awareness (mostly in children)
MyoclonicSudden jerks of arms or legs
AtonicSudden loss of muscle tone; may fall
TonicMuscle stiffening
ClonicRepetitive jerking movements

🔍 CAUSES & RISK FACTORS

CategoryExamples
GeneticInherited epilepsy syndromes
Brain injuryHead trauma, stroke, birth injury
InfectionsMeningitis, encephalitis, neurocysticercosis
Structural brain issuesTumors, malformations
Metabolic issuesLow blood sugar, electrolyte imbalance
Unknown (idiopathic)No identifiable cause

🧪 DIAGNOSIS

  • Electroencephalogram (EEG): Measures brain electrical activity

  • MRI/CT scans: Identify structural brain problems

  • Blood tests: Rule out infections, metabolic causes

  • Neurological evaluation: History + symptom patterns


💊 TREATMENT OPTIONS

🔹 1. Medications (Antiepileptic Drugs - AEDs)

Common AEDsNotes
Levetiracetam (Keppra)Well-tolerated, few interactions
Valproate (Depakote)Broad-spectrum, not safe in pregnancy
Lamotrigine (Lamictal)Good for focal and generalized seizures
Carbamazepine (Tegretol)Effective for focal seizures
Phenytoin, Topiramate, LacosamideOthers based on seizure type

✅ 70% of people achieve good control with meds
⚠️ Requires regular monitoring for side effects and drug levels


🔹 2. Surgical Treatments (For drug-resistant epilepsy)

TypePurpose
LobectomyRemoves seizure-producing brain area
Laser ablationMinimally invasive destruction of small brain tissue
Corpus callosotomyPrevents seizure spread between hemispheres
HemispherectomyFor severe cases in children

🔹 3. Neuromodulation

DeviceFunction
Vagus Nerve Stimulator (VNS)Sends electrical pulses to the brain
Responsive Neurostimulation (RNS)Detects and blocks seizures
Deep Brain Stimulation (DBS)Targets specific brain regions

🔹 4. Dietary Therapy

DietWho it helps
Ketogenic diet (high-fat, low-carb)Children with drug-resistant epilepsy
Modified Atkins or low glycemic index dietMore flexible alternatives

🔹 5. Lifestyle & Supportive Care

  • Medication adherence is critical

  • Avoid triggers: lack of sleep, alcohol, stress

  • Use medical alert ID

  • Regular follow-up with a neurologist

  • Education on seizure first aid


🚨 SEIZURE FIRST AID

✅ Stay calm
✅ Lay the person on their side
✅ Protect their head
✅ Do not restrain or put anything in their mouth
✅ Call emergency services if:

  • Seizure lasts >5 minutes

  • Person doesn’t regain consciousness

  • It's their first seizure


🩺 PROGNOSIS

  • ~70% of people can live seizure-free with treatment

  • Some may outgrow epilepsy or enter long-term remission

  • Others may need lifelong management, especially with comp

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