Beer sales are down.

For more than two decades, pints of lagers and ales flowed from the taps at 21st Amendment Brewery.

An early mover in craft brewing, the bar and restaurant flourished in San Francisco’s South Park neighborhood, near the financial district and the Giants’ Oracle Park, serving its own specialties like Hell or High Watermelon beer.

But after 25 years, 21st Amendment, named after the constitutional amendment that made alcohol legal after Prohibition, will say “last call” for the final time later this month as it shuts its doors.

What’s happened to 21st Amendment isn’t unique, as craft breweries across the country shutter or file for bankruptcy at a rapid rate.

Sales of craft beer fell 4 percent last year, according to the Brewers Association, the lobbying arm for small and independent brewers. There have been more brewery closings than openings over the past 18 months, the first time that has happened in 20 years.